HORDB

ID: hor002093
Uniprot ID: Q9TRM8
Protein name: Relaxin A chain
Gene name: RLN
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Family: Insulin family
Source: animal
Expression: Placenta; syncytiotrophoblast.
Disease: NA
Comments: NA
Taxonomy: Canis lupus (species), Canis (genus), Canidae (family), Caniformia (suborder), Carnivora (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Sequence: DNYIKMSDKCCNVGCTRRELASRC
Length: 24(154-177)
Propeptide: MLRWFLSHLLGVWLLLSQLPREIPATDDKKLKACGRDYVRLQIEVCGSIWWGRKAGQLRERRQISEPLAEVVPSSIINDPEILSLMLQSIPGMPQELRIATRSGKEKLLRELHFVLEDSNLNLEEMKKTFLNTQFEAEDKSLSKLDKHPRKKRDNYIKMSDKCCNVGCTRRELASRC
Signal peptide: MLRWFLSHLLGVWLLLSQLPREIPA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.
Mechanism: NA
Cross BBB: NA
Target: RXFP2
Target Unid: Q5XM32
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002093_AF2.pdb

hor002093_ESM.pdb

Mass:	317663	Formula:	C109H185N37O37S5
Absent amino acids:	FHPQW	Common amino acids:	C
pI:	8.33	Basic residues:	5
Polar residues:	11	Hydrophobic residues:	4
Hydrophobicity:	-69.17	Boman Index:	-7880
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	48.75
Instability Index:	7633.75	Extinction Coefficient cystines:	1740
Absorbance 280nm:	75.65